No. Most multipliers work best between 25KHz and 150KHz. There are exceptions to the rule, but generally the absolute minimum operating frequency is 10KHz.

Operating frequency directly impacts

  • Ripple voltage (the higher the operating frequency, the lower the ripple voltage)
  • Regulation voltage (the higher the operating frequency, the less drop in output voltage at load)

Higher operating frequencies have greater efficiency in the multiplier. For a slow 60hz signal, very large capacitances would be required to regulate the voltage
properly and have a consistent high voltage output.